Welcome to Oligovax !

Oligovax is a biopharmaceutical company focused on developing innovative therapies for cancer.

The company’s leads molecule, Litenimod, is potent agonist of toll Like receptor 9 (TLR9), triggering both innate and adaptive immune response.


Such a mechanism of action provides the potential to use Litenimod either alone, or as a vaccine adjuvant, or combined to monocolonal antibodies.

Oligovax has successfully completed several clinical trials in cancer, and is conducting pre-clinical studies using Litenimod as an adjuvant in vaccine and/or immunotherapeutic approaches.

Gentaur Group


 

A Research Viewpoint

Oligovax is a biopharmaceutical company focused on developing innovative therapies for cancer.


Schematic of the two working modes of cancer vaccine adjuvants. (I) Adjuvants are additives in the vaccine formulation. (II) Adjuvants induce in situ immune activation together with tumor antigens produced by immunogenic cell death resulting from cancer treatment (radiotherapy, chemotherapy, and oncolytic virus treatment). Adapt with permission from ref. 16, Mount Sinai Health System.

 

The company’s leads molecule, Litenimod, is potent agonist of Toll Like Receptor 9 (TLR9), triggering both innate and adaptive immune response.

Such a mechanism of action provides the potential to use Litenimod either alone, or as a vaccine adjuvant, or combined to monocolonal antibodies.

Oligovax has successfully completed several clinical trials in cancer, and is conducting pre-clinical studies using Litenimod as an adjuvant in vaccine and/or immunotherapeutic approaches.


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What Is TLR9 ?

Understanding Toll-Like Receptor 9 in Innate Immunit

TLR9 (Toll-Like Receptor 9) is a critical component of the innate immune system, primarily responsible for recognizing unmethylated CpG motifs in viral and bacterial DNA. Found in endosomal compartments of immune cells like plasmacytoid dendritic cells and B cells, TLR9 plays a pivotal role in immune surveillance and inflammation.

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The Function of TLR9 : How Does It Work ?

TLR9 (Toll-Like Receptor 9) is a critical component of the innate immune system, primarily responsible for recognizing unmethylated CpG motifs in viral and bacterial DNA. Found in endosomal compartments of immune cells like plasmacytoid dendritic cells and B cells, TLR9 plays a pivotal role in immune surveillance and inflammation.

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List of Vaccine Companies in Belgium:

1. GSK Vaccines (GlaxoSmithKline)


Website: GSK company website (Since a dedicated vaccines website isn't available, this points to the main GSK website)

Description: A global leader in vaccine development and production, offering a broad portfolio of vaccines for various diseases like shingles, influenza, and cervical cancer. They are known for their innovation and commitment to global health initiatives.

2. Pfizer


Website: https://www.pfizer.com/

Description: A major biopharmaceutical company with a significant presence in Belgium. They co-developed the well-known COVID-19 vaccine and are actively involved in research for new vaccines against other infectious diseases and cancers.

3. Janssen Pharmaceutica (Johnson & Johnson)


Website: https://www.janssen.com/

Description: A subsidiary of Johnson & Johnson, Janssen Pharmaceutica is a major player in vaccine development. They contribute significantly to global health by creating vaccines for various infectious diseases like HIV, Ebola, and respiratory syncytial virus (RSV).

4. UCB Pharma


Website: https://www.ucb.com/

Description: Headquartered in Belgium, UCB Pharma specializes in research, development, and commercialization of biopharmaceuticals, including vaccines for diseases like meningitis and shingles. They are also involved in developing treatments for neurological and immunological disorders.

5. PDC*line Pharma


Website: https://www.pdc-line-pharma.com/

Description: A Belgian clinical-stage biotech company with a unique approach. They are developing innovative therapeutic cancer vaccines based on a specific cell line (PDC*line) with the goal of creating personalized and more effective cancer treatments.

6. eTheRNA Immunotherapies


Website: https://www.etherna.be/

Description: A pioneer in mRNA-based immunotherapies. Located in Belgium, they are at the forefront of developing novel vaccines and treatments for cancer and infectious diseases. Their mRNA technology holds promise for creating highly targeted and adaptable therapies.

7. Univercells


Website: https://www.univercells.com/

Description: A Belgian biotech company focused on making biologics, including vaccines, more affordable and accessible. They achieve this through innovative manufacturing technologies that aim to streamline production processes.

8. Imcyse


Website: https://www.imcyse.com/

Description: This company develops specific active immunotherapies, a type of vaccine, to address severe chronic diseases. Their focus is on areas like autoimmune diseases and allergies, aiming to provide preventative and therapeutic solutions.

9. Biocartis


Website: https://www.biocartis.com/en

Description: While primarily known for their diagnostic solutions, Biocartis also plays a role in vaccine development. They create companion diagnostics, which are specialized tests used to assess the effectiveness of vaccines and other biological therapies.

10. Quality Assistance


Website: https://www.quality-assistance.com/

Description: This company provides crucial analytical support for the development and production of vaccines and other biologics. Their services ensure that these products meet strict regulatory standards for safety and efficacy.

Additional Companies to Consider:


Innogenetics: A company specializing in personalized medicine and infectious disease diagnostics, with potential involvement in vaccine development.

IBA (Ion Beam Applications): Provides particle accelerator technology used in research and pre-clinical development of vaccines and other therapies.

Oligovax suppliers

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ABclonal
AbMole
Abvigen
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AdooQ Bioscience
Affinity Biosciences
AFG Scientific
Alphabioregen
Ampliqon A/S
ApexBio
ArborAssays Inc
ArticZymes
ArtMolecule
Artron Bioresearch Inc
Assay Vector
AssayPro Inc
Aurora Biolabs
Bertin Pharma (formerly SPI Bio)
Bio Australis
BioAssayWorks LLC
Bioclone Inc
Biologix
Biomatik LLC
Biomedical Technologies Inc
Bioquote Limited
Biosolution
Biotool
bioWorld Inc
BOC Sciences
BPS Bioscience Inc
Cellular Engineering Technologies Inc
Celprogen
CHI Scientific
ClaremontBio
Creative Biogene
Creative Biomart
Creative Diagnostics
Crystalgen Inc
CSNpharm
Cusabio
Cytoskeleton Inc
Emerald Bio
Eurobio
Genesis Biotech
GenomeMe
Glantreo
Globozymes Inc
GlycoMatrix Inc
iAwareables
Immunospec Corporation
Indigo Biosciences
Intact Genomics
Jena Bioscience GmbH
Kamiya Biomedical Inc
Komabiotech
Krishgen Biosystems
Labfrontier
Lumigen Inc
Lumiprobe GmbH
Matexcel
MedChemExpress
Membrane Solutions Inc
Mgenex Biosciences
Michigan Diagnostics
Microlytic Inc
Micron Separations Inc
MiTeGen Inc
Molnova
NanoHelix Co. Ltd
Norgen Biotek Corporation
NSJ Bioreagents
Oxyrase Inc
Paras Biopharmaceuticals Finland Oy
PriCella
Pro Sci
Prospec - Tany TechnoGene Ltd
R-Biopharm
Reagen LLC
Scientific Specialties Inc
Selleckchem Inc
Signet Pathology Systems
Sorenson Bioscience Inc
Stressmarq Biosciences
TargetMol
Teknova Inc
TOKU-E
Toronto Research Chemicals
Tribioscience Inc

Tridelta Development Ltd
Viagen Biotech Inc
Visual Protein
Xylyx Bio
Zellbio
Gentaur Yeasen




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